The Antimicrobial Action of Certain Glycerol
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چکیده
After it had been shown that the phenyl ether of ethylene glycol possessed antibacterial properties against Pseudomonas aerunosa (Berry, 1944) the antimicrobial and pharmacological activities of a number of related compounds were evaluated. Two of the compounds investigated in this connection have found clinical usefulness. These are mephenesin,3-o-toloxy-1, 2propanediol, widely used as a muscle relaxant (Berger and Bradley, 1946) and chlorophenesin, 3-p-chlorophenoxy-1 ,2-propanediol, used in the treatment of fungus infections of the skin (Hartley, 1947). The object of the investigation reported here was to study the antibacterial and antifungal action, the toxicity and other biological properties of some simple methylated and chlorinated phenyl ethers of glycerol, propylene glycol and trimethylene glycol and to attempt to relate these properties with the chemical structure and physical properties of the compounds. This study has brought to light several compounds with substantially higher antibacterial and antifungal action than chlorophenesin.
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تاریخ انتشار 2005